The natural history report is a standardized summary of information about populations of interest. Natural history information is descriptive, with the intent to provide some context and expected rates of drug utilization and condition occurrence to facilitate the interpretation of benefit and risk information. Observational data offers potential value in providing summary information, both about the populations that experience a condition (the disease natural history) as well as the populations that are exposed (natural history of drug utilization). The Natural History Analysis program, NATHAN, produces a standardized report to summarize characteristics about the population of interest, including demographic factors (age and gender), co-morbidities and concomitant medications, and health service utilization prior to, during, and after the event onset.
Download NATHAN Specification and SAS Code:
NATHAN Specification, Code and Release Notes
The Observational Source Characteristics Analysis Report (OSCAR) provides a systematic approach for summarizing all data within the OMOP common data model. NATHAN is an extension of OSCAR, where data characteristics can be produced for a particular subpopulation of interest. When OSCAR is used on a data source, the following questions are addressed for all patients represented in the data:
When using NATHAN, the same questions can be answered for subgroups of patients. For example, “For patients with an MI, how many had an exposure to a particular drug?” NATHAN takes this a step further and provides some temporal association. From the first MI, NATHAN can address: